New Insights into Malignant B-Cell Disorders
نویسندگان
چکیده
منابع مشابه
New Insights into Malignant B-Cell Disorders
Mature B-cell disorders comprise numerous and very different entities including all B-cell lymphomas (NHL) subgroups , chronic lymphocytic leukemia (CLL), and plasma cell dyscrasias [1]. Growing knowledge on disease biology has led to the development of new drugs, while innovative diagnostic techniques have resulted in improvement of diagnosis, establishment of new prognostic factors, and the r...
متن کاملNew Insights into Monoclonal B-Cell Lymphocytosis
Monoclonal B-cell lymphocytosis (MBL) is a premalignant condition characterized by the presence of less than 5000/μL circulating clonal B cells in otherwise healthy individuals. Three subcategories have been identified according to the immunophenotypic features: CLL-like, CD5(+) atypical, and CD5(-) MBL. CLL-like MBL is by far the most frequent and best studied category and further divided in l...
متن کاملNew insights into malignant cell survival mechanisms in medulloblastoma.
mRNA translation and protein synthesis is an important determinant for cell metabolism and cell homeostasis. Perturbations in cellular homeostasis often result in activation of negative feedback loops as compensatory mechanisms. Although, these mechanisms are important for mammalian cells to adjust to environmental changes, they also pose a major challenge for targeted cancer therapy as they pr...
متن کاملNew insights into merkel cell carcinoma.
Merkel cell carcinoma (MCC) is a rare aggressive cutaneous malignancy of the elderly and immunocompromised populations. The clinical presentation of MCC is nonspecific, with the majority of cases presenting as localized skin involvement. Histologically and immunophenotypically, MCC is defined by both neuroendocrine and epithelial differentiation. Recently, the Merkel cell polyomavirus has been ...
متن کاملMatrix Metalloproteinases, New Insights into the Understanding of Neurodegenerative Disorders
Matrix metalloproteinases (MMPs) are a subfamily of zinc-dependent proteases that are responsible for degradation and remodeling of extracellular matrix proteins. The activity of MMPs is tightly regulated at several levels including cleavage of prodomain, allosteric activation, compartmentalization and complex formation with tissue inhibitor of metalloproteinases (TIMPs). In the central nervous...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BioMed Research International
سال: 2015
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2015/128084